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中南大学学报(自然科学版)

Journal of Central South University

第42卷    第5期    总第201期    2011年5月

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文章编号:1672-7207(2011)05-1232-06
纳米羟基磷灰石/壳聚糖载药微球的制备及性能
李湘南1, 2,陈晓明1,彭志明1,李世普1

(1. 武汉理工大学 生物材料与工程研究中心,湖北 武汉,430070;
2. 武汉理工大学 化工学院,湖北 武汉,430070
)

摘 要: 以纳米羟基磷灰石和壳聚糖为基质,构建一种新型甲硝唑缓释微球,作为充填材料用于骨修复。利用乙醇为反应溶剂,聚丙烯酸为分散剂,在pH=11的条件下,制备针状纳米羟基磷灰石。采用W/O 型反相乳化-交联技术制备羟基磷灰石/壳聚糖载甲硝唑复合微球。通过紫外分光光度法测定甲硝唑含量和体外累积释放度。研究结果表明:制得的羟基磷灰石/壳聚糖载药复合微球粒径主要集中在1~10 μm,壳聚糖对羟基磷灰石和甲硝唑形成了很好的包覆。复合微球平均载药量为38.23%,平均包封率为54.21%,3 d内对甲硝唑的释放达到82%左右。所制备的羟基磷灰石/壳聚糖载药复合微球形态圆整,粒径分布较为均匀,对甲硝唑具有较好的缓释效果。

 

关键字: 缓释微球;甲硝唑;纳米羟基磷灰石;壳聚糖

Preparation and performance of drug-loaded nano-hydroxyapatite/chitosan microspheres
LI Xiang-nan1, 2, CHEN Xiao-ming1, PENG Zhi-ming1, LI Shi-pu1

1. Biomedical Materials and Engineering Research Center, Wuhan University of Technology, Wuhan 430070, China;
2. College of Chemical Engineering, Wuhan University of Technology, Wuhan 430070, China

Abstract:Nano-hydroxyapatite and chitosan were selected as matrix to prepare a novel metronidazole sustained release microsphere for bone tissue recovery. Aciform nano-hydroxyapatite was synthesized in ethanol medium (pH=11) using polyacrylic acid as dispersant. Metronidazole-loaded chitosan/hydroxyapatite composite microspheres were prepared by water in oil emulsion cross-linking method. The results show that the size of as-fabricated composite microspheres is mainly distributed from 1 to 10 μm, and hydroxyapatite and metronidazole are embedded very well by chitosan. The average drug loading is 38.23%, the average entrapment efficiency is 54.21%, and the cumulative release rate to metronidazole is near 82% during 3 d. The composite microspheres are spherical and distributed uniformly in diameter with a good property for the slow-release of metronidazole, which have great potential in drug delivery system.

 

Key words: sustained release microsphere; metronidazole; nano-hydroxyapatite; chitosan

中南大学学报(自然科学版)
  ISSN 1672-7207
CN 43-1426/N
ZDXZAC
中南大学学报(英文版)
  ISSN 2095-2899
CN 43-1516/TB
JCSTFT
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