自然科学版 英文版
自然科学版 英文版
自然科学版 英文版

您目前所在的位置:首页 - 期刊简介 - 详细页面

中南大学学报(英文版)

Journal of Central South University

Vol. 9    No. 1    March 2002

[PDF Download]    [Flash Online]

    

Synthesis and characterization of
2-hydroxy-N-methyl-N-phenyl-acetamide
ZHOUZhong-cheng(周忠诚),SHUWan-yin(舒万艮)

College ofChemistry and Chemical Engineering, Central South University, Changsha410083, China

Abstract:2-hydroxy-N-methyl-N-phenyl-acetamide was synthesized by using N-methylaniline, chloracetyl chloride, anhydrous sodium acetate and methanol through the acetylation, esterfication and ester interchange steps. The acetylation of N-methylaniline with chloracetyl chloride, catalyzed by triethylamide with mole ratio n(C6H5NHCH3)∶n(ClCH2C(O)Cl)∶n(N(C2H5)3)=1∶1.05∶1, the yield of 2-chloro-N-methyl-N-phenyl-acetamide(Ⅰ) was 93.8%; Then the esterification ofⅠwith anhydrous sodium acetate in the presence of phase transfer catalyst tetrabutyl ammonia bromide gave 97.3% yield of 2-acetoxyl-N-methyl-N-phenyl-ac-etamide (Ⅱ); The ester interchange of with methanol catalyzed by potassium hydroxide gave 2-hydroxy-N-methyl-N-phenyl-acetamide (Ⅲ) in 96.4% yield. And the total yield was 88.0%. IR and MS spectroscopy of products were analyzed and their characteristic peaks were assigned. Combining the results of elemental analysis, the molecular structure ofⅠ,ⅡandⅢwas identified.

 

Key words: -N-methyl-N-phenyl-acetamide; synthesis; acetylation; esterfication; ester interchange; char-acterization

中南大学学报(自然科学版)
  ISSN 1672-7207
CN 43-1426/N
ZDXZAC
中南大学学报(英文版)
  ISSN 2095-2899
CN 43-1516/TB
JCSTFT
版权所有:《中南大学学报(自然科学版、英文版)》编辑部
地 址:湖南省长沙市中南大学 邮编: 410083
电 话: 0731-88879765 传真: 0731-88877727
电子邮箱:zngdxb@csu.edu.cn 湘ICP备09001153号